Genetics and cardiovascular disease - 1981.
نویسندگان
چکیده
منابع مشابه
Genetics of cardiovascular disease.
Fifty years ago, cardiovascular genetics simply did not exist. Genetics was a nascent field of basic research, with little apparent relevance to cardiovascular science or any other medical subspecialty. Today, cardiovascular genetics is a discipline that fully integrates high-technology laboratory investigation and clinical medicine. From this hybrid have emerged discoveries that have precisely...
متن کاملGenetics of Human Cardiovascular Disease
Cardiovascular disease encompasses a range of conditions extending from myocardial infarction to congenital heart disease, most of which are heritable. Enormous effort has been invested in understanding the genes and specific DNA sequence variants that are responsible for this heritability. Here, we review the lessons learned for monogenic and common, complex forms of cardiovascular disease. We...
متن کاملGenetics of Hypertension and Cardiovascular Disease
With the force something like a tsunami wave, a surge of genome-wide association studies (GWASs) in common complex diseases has flooded the recent literature and left us awash with data regarding the identification of causative genetic risk factors for cardiovascular disease such as hypertension. Nevertheless, the more slowly moving tide of the classical candidate gene approach also makes stead...
متن کاملGenetics and tailored therapy in cardiovascular disease
Can we today apply genetics to individual patients and tailor therapy based on genetic profile to improve pharmacodynamics and kinetics [1]? This is an interesting question especially for the treatment of hypertension as substantial heterogeneity in efficacy exists in response to drug therapy. Individualised medicine may guide physicians in their choice instead of the old-fashioned trial-and-er...
متن کاملIron and the genetics of cardiovascular disease.
The hypothesis that iron depletion protects against ischemic heart disease was proposed in 1981 as an explanation for the sex difference in heart disease rates.1–5 The “iron hypothesis” has generated significant debate, especially in the 1990s after publication of supportive findings from Finland.6 Confusion has been introduced into the debate by inappropriate study designs in tests of the hypo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Japanese Circulation Journal
سال: 1982
ISSN: 0047-1828,1347-4839
DOI: 10.1253/jcj.46.1